Publications

February 6, 2025 Tissue Engineering Part A

Matrix-Bound Nanovesicles Promote Prohealing Immunomodulation Without Immunosuppression

Héctor Capella-Monsonís, MSc, PhD, Raphael J. Crum, PhD, William D’Angelo, PhD, George S. Hussey, PhD, and Stephen F. Badylak, DVM, PhD, MD

May 19, 2023 Science Advances

Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles

Raphael J. Crum, Brydie R. Huckestien, Gaelen Dwyer, Lisa Mathews, David G. Nascari, George S. Hussey, John F. Alcorn, Stephen F. Badylak

November 22, 2022 Sciences Advances

Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo

Raphael J. Crum, Héctor Capella-Monsonís, Jordan Chang, Marley J. Dewey, Brian D. Kolich, Kelsey T. Hall, Salma O. El-Mossier, David G. Nascari , George S. Hussey, Stephen F. Badylak

November 8, 2022 Tissue Engineering Part A

Matrix Bound Nanovesicles Have Tissue-Specific Characteristics That Suggest a Regulatory Role

Neill J. Turner, Lina M. Quijano, George S. Hussey, Peng Jiang, and Stephen F. Badylak

October 13, 2022 Tissue Engineering Part A

Transcriptomic Regulation of Macrophages by Matrix-Bound Nanovesicle-Associated Interleukin-33

Madeline Cramer, Catalina Pineda Molina, George Hussey, Heth R. Turnquist, and Stephen F. Badylak

October 11, 2022 Tissue Engineering Part A

Transcriptomic, Proteomic, and Morphologic Characterization of Healing in Volumetric Muscle Loss

Raphael J. Crum, Scott A. Johnson, Peng Jiang, Jayati H. Jui, Ruben Zamora, Devin Cortes, Mangesh Kulkarni, Archana Prabahar, Jennifer Bolin, Eric Gann, Eric Elster, Seth A. Schobel, Dale Larie, Chase Cockrell, Gary An, Bryan Brown, Milos Hauskrecht, Yoram Vodovotz, and Stephen F. Badylak

February 22, 2022 Nature Regenerative Medicine

Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis

Raphael J. Crum, Kelsey Hall, Catalina Pineda Molina, George S. Hussey, Emma Graham, Hongshuai Li and Stephen F. Badylak

February 21, 2022 Oncotarget

A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo

Mark H. Murdock, George S. Hussey, Jordan T. Chang, Ryan C. Hill, David G. Nascari, Aparna V. Rao, Kirk C. Hansen, Lesley M. Foley, T. Kevin Hitchens, Nduka M. Amankulor and Stephen F. Badylak

January 29, 2022 Science Direct Elsevier

Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using 19F MRI

Michel Modo, Harmanvir Ghuman, Reem Azar, Ryan Krafty, Stephen F.Badylak, T. Kevin Hitchens.

December 22, 2020 Journal of Immunology and Regenerative Medicine

The effect of normal, metaplastic, and neoplastic esophageal extracellular matrix upon macrophage activation

Lindsey T.Saldin, Molly Klimaka, Ryan C.Hill, Madeline C. Cramer, Luai Huleihel, Xue Li, Maria Quidgley-Martina, David Cardenas, Timothy J. Keane, Ricardo London, George Hussey, Lori Kelly, Juliann E. Kosovec, Emily J. Lloyd, Ashten N. Omstead, Li Zhang, Alejandro Nieponice, Blair Jobe, Stephen F. Badylak

December 8, 2020 ScienceDirect Elsevier

ECM hydrogel improves the delivery of PEG microsphere-encapsulated neural stem cells and endothelial cells into tissue cavities caused by stroke

Harmanvir Ghuman, Rita Matta, Alexandra Tompkins, Franziska Nitzsche, Stephen F. Badylak, Anjelica L. Gonzalez, Michel Modo

October 19, 2020 Tissue Engineering

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function

Lina M. Quijano, Juan D. Naranjo, Salma O. El-Mossier, Neill J. Turner, Catalina Pineda Molina, Joseph Bartolacci, Li Zhang, Lisa White, Hui Li, and Stephen F. Badylak

July 9, 2020 The Journal of Clinical Investigation

Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection

Teng fang Li, Zhong qiang Zhang, Joe G. Bartolacci, Gaelen K. Dwyer, Quan Liu, Lisa R. Mathews, Murugesan Velayutham, Anna S. Roessing, Yoojin C. Lee, Helong Dai, Sruti Shiva, Martin H. Oberbarnscheidt, Jenna L. Dziki, Steven J. Mullet, Stacy G. Wendell, James D. Wilkinson, Steven A. Webber, Michelle Wood-Trageser, Simon C. Watkins, Anthony J. Demetris, George S. Hussey, Stephen F. Badylak, and Hēth R. Turnquist

July 1, 2020 Science Advances

Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett’s esophagus

Juan Diego Naranjo, Lindsey T. Saldin, Eric Sobieski, Lina M. Quijano, Ryan C. Hill, Patrick G. Chan, Crisanto Torres, Jenna L. Dziki, Madeline C. Cramer, Yoojin C. Lee, Rohit Das, Anant K. Bajwa, Rania Nossair, Molly Klimak, Lucile Marchal, Shil Patel, Sachin S. Velankar, Kirk C. Hansen, Kevin McGrath, Stephen F. Badylak

March 20, 2020 Science Advances

Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials

George S. Hussey, Catalina Pineda Molina, Madeline C. Cramer, Yulia Y. Tyurina, Vladimir A. Tyurin, Yoojin C. Lee, Salma O. El-Mossier, Mark H. Murdock, Peter S. Timashev, Valerian E. Kagan, Stephen F. Badylak

March 5, 2019 Nature Scientific Reports

Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function

Yolandi van der Merwe, Anne E. Faust, Ecem T. Sakalli, Caroline C. Westrick, George Hussey, Ian P. Conner, Valeria L. N. Fu, Stephen F. Badylak & Michael B. Steketee

February 1, 2019 Journal of Immunology and Regenerative Medicine

Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway

George S. Hussey, Jenna L. Dziki, Yoojin C. Lee, Joseph G. Bartolacci, Marissa Behun, Hēth R. Turnquist, Stephen F. Badylak

December 26, 2018 Journal of Immunology and Regenerative Medicine

Comparison of the host macrophage response to synthetic and biologic surgical meshes used for ventral hernia repair

Catalina Pineda Molina, Ross Giglio, Riddhi M. Gandhi, Brian M. Sicari, Ricardo Londono, George S. Hussey, Joseph G. Bartolacci, Lina M. Quijano Luque, Madeline C. Cramer, Jenna L. Dziki, Peter M. Crapo, Stephen F. Badylak

October 15, 2018 Acta Biomaterialia

Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke

Harmanvir Ghuman, Carrinton Mauney, Julia Donnelly, Andre R. Massensini, Stephen F. Badylak, Michel Modo

October 12, 2018 Tissue Engineering

Human testis extracellular matrix enhances human spermatogonial stem cell survival in vitro

Mr. Mark H. Murdock, Miss Sherin David, Miss Ilea T. Swinehart, Mrs. Janet E. Reing, Miss Kien Tran, Dr. Kathrin Gassei, Dr. Kyle E. Orwig, Dr. Stephen F Badylak

September 28, 2018 The Journal of Thoracic and Cardiovascular Surgery

Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applications

Mark H. Murdock, BSc, Jordan T. Chang, BA, Samuel K. Luketich, MS, Drake Pedersen, BSc, George S. Hussey, PhD, Antonio D’Amore, PhD, and Stephen F. Badylak, MD, PhD, DVM

September 27, 2018 Tissue Engineering

Extracellular matrix degradation products downregulate neoplastic esophageal cell phenotype

Miss Lindsey Tamiko Saldin, Mr. Shil Patel, Dr. Li Zhang, Dr. Luai Huleihel, Dr. George S. Hussey, Mr. David Gabriele Nascari, Dr. Lina Maria Quijano, Dr. Xue Li, Miss Divya Raghu, Miss Anant Kaur Bajwa, Mr. Nicholas G. Smith, Mr. Christopher Chi-Heng Chung, Miss Ashten N. Omstead, Miss Juliann E. Kosovec, Dr. Blair A. Jobe, Dr. Neill J Turner, Dr. Ali H. Zaidi, and Dr. Stephen F Badylak

May 29, 2018 Nature Reviews Materials

Extracellular matrix-based materials for regenerative medicine

George S. Hussey, Jenna L. Dziki & Stephen F. Badylak

September 10, 2016 Journal of Crohn's and Colitis

Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis

Timothy J. Keane, Jenna Dziki, Eric Sobieski, Adam Smoulder, Arthur Castleton, Neill Turner, Lisa J. White, Stephen F. Badylak

July 21, 2016 npj Regenerative Medicine

An acellular biologic scaffold treatment for volumetric muscleloss: results of a 13-patient cohort study

Jenna Dziki, Stephen Badylak, Mohammad Yabroudi, Brian Sicari, Fabrisia Ambrosio, Kristen Stearns, Neill Turner, Aaron Wyse, Michael L Boninger, Elke HP Brown and J Peter Rubin

June 10, 2016 Science Advances

Matrix-bound nanovesicles within ECM bioscaffolds

Luai Huleihel, George S. Hussey, Juan Diego Naranjo, Li Zhang, Jenna L. Dziki, Neill J. Turner, Donna B. Stolz, Stephen F. Badylak

August 12, 2015 Tissue Engineering

Tissue-Specific Effects of Esophageal Extracellular Matrix

Timothy J. Keane, Aaron DeWard, Ricardo Londono, Lindsey T. Saldin, Arthur A. Castleton, Lisa Carey, Alejandro Nieponice, Eric Lagasse, and Stephen F. Badylak

March 28, 2011 Tissue Engineering

Esophageal Preservation in Five Male Patients After Endoscopic Inner-Layer Circumferential Resection in the Setting of Superficial Cancer: A Regenerative Medicine Approach with a Biologic Scaffold

Stephen F. Badylak, Toshitaka Hoppo, Alejandro Nieponice, Thomas W. Gilbert, Jon M. Davison, and Blair A. Jobe